Cholesterol Synthesis, Cholesterol Absorption, and Mortality in Hemodialysis Patients
نویسندگان
چکیده
منابع مشابه
Cholesterol synthesis, cholesterol absorption, and mortality in hemodialysis patients.
BACKGROUND AND OBJECTIVES Recent clinical trials on cholesterol-lowering in patients with CKD yielded conflicting results, which might have resulted from different treatment strategies. Serum cholesterol levels are determined by endogenous synthesis and intestinal absorption, which are differentially influenced by various classes of cholesterol-lowering agents. Assessing markers of cholesterol ...
متن کاملThe interaction of cholesterol absorption and cholesterol synthesis in man.
The total miscible pool of cholesterol in the body is determined largely by the interaction of cholesterol absorption and synthesis. In the present study we have examined the net effects of this interplay in one normal and five hypercholesteremic subjects when various amounts of cholesterol were made available for absorption. Feeding large amounts of cholesterol to the normocholesteremic patien...
متن کاملIntestinal cholesterol absorption, treatment with atorvastatin, and cardiovascular risk in hemodialysis patients.
BACKGROUND Hemodialysis patients are high absorbers of intestinal cholesterol; they benefit less than other patient groups from statin therapy, which inhibits cholesterol synthesis. OBJECTIVES This study sought to investigate whether the individual cholesterol absorption rate affects atorvastatin's effectiveness to reduce cardiovascular risk in hemodialysis patients. METHODS This post-hoc a...
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Type 2 diabetes has been associated with high synthesis and low absorption of cholesterol independent of weight, indicating that insulin resistance may be a link between glucose and cholesterol metabolism. Therefore, we investigated the relationship of serum cholesterol precursors, reflecting cholesterol synthesis, and serum plant sterols and cholestanol, reflecting cholesterol absorption effic...
متن کاملThe Relationship Between Cholesterol Absorption and Intestinal Cholesterol Synthesis in the Diabetic Rat Model
The chylomicron remnant particle is thought to be particularly atherogenic and we have previously shown alterations in post-prandial lipoproteins which could contribute to their atherogenicity. Cholesterol metabolism is disturbed in diabetes, yet the effect of diabetes on intestinal cholesterol synthesis and absorption has rarely been investigated. The aim of this study was to examine cholester...
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2012
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.05170511